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猪水疱病病毒对新生小鼠的蚀斑形态及致病性。I. 野生毒株及其克隆株

Plaque morphology and pathogenicity for newborn mice of swine vesicular disease virus. I. Wild strains and their clones.

作者信息

Niemiałtowski M

出版信息

Acta Virol. 1983 May;27(3):217-22.

PMID:6138982
Abstract

The population of wild swine vesicular disease virus (SVDV) strains was found non-homogeneous as manifested by varying plaque size and different pathogenicity of the clones obtained. The clones derived from large plaques (5-9 mm)--dominating among wild strains--were more virulent for newborn mice than those obtained from smaller plaques (1-2 mm). To evaluate the pathogenicity of wild SVDV strains the dose index was calculated; the clones were compared by dose index and theoretical pathogenicity index, respectively.

摘要

野生猪水泡病病毒(SVDV)毒株群体表现出非均一性,这体现在所获得克隆的蚀斑大小各异以及致病性不同。从大蚀斑(5 - 9毫米)——在野生毒株中占主导地位——衍生出的克隆对新生小鼠的毒性比从小蚀斑(1 - 2毫米)获得的克隆更强。为评估野生SVDV毒株的致病性,计算了剂量指数;分别通过剂量指数和理论致病性指数对克隆进行比较。

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