Spondylarthropaty Group, Division of Rheumatology, Hospital Militar/Universidad de La Sabana, Bogotá, Colombia.
Rheumatol Int. 2012 Jul;32(7):2195-7. doi: 10.1007/s00296-011-1883-1. Epub 2011 Jul 16.
The pathogenesis of SpA is considered to be a complex and multi-factorial process and, similar to other autoimmune diseases, includes the activity of proinflammatory cytokines such as TNF alpha. Our study compared the -308 promoter polymorphism of TNF alpha with TNF alpha levels, HLA-B27 status, age at the onset of symptoms, SpA subtype and the clinical degree of activity in Colombian SpA patients and healthy subjects (HS). Comparisons of the TNF alpha-308A genotype among HS and SpA patients (P = 0.004), uSpA patients (P = 0.040), ReA patients (P = 0.001), were significantly different and AS patients (P = 0.110), as were alleles for SpAs (P = 0.007) between patients with SpAs and controls. Initial exploratory analyses demonstrated that the TNF alpha-308 SNP genotype frequencies were different among SpA patients and HS in the Colombian population studied. Furthermore, there was no significant correlation with activity and functional clinical index, serum TNF alpha level or HLA B27 status. Allele frequencies, on the other hand, were correlated with the activity clinical index.
SpA 的发病机制被认为是一个复杂的多因素过程，与其他自身免疫性疾病类似，包括 TNF-α 等促炎细胞因子的活性。我们的研究比较了 TNF-α 的-308 启动子多态性与 TNF-α 水平、HLA-B27 状态、症状发作年龄、SpA 亚型和哥伦比亚 SpA 患者的临床活动程度。健康对照组和 SpA 患者（P = 0.004）、uSpA 患者（P = 0.040）、ReA 患者（P = 0.001）之间 TNF-α-308A 基因型的比较差异有统计学意义，SpA 患者的等位基因也存在差异（P = 0.007）。与对照组相比。初步探索性分析表明，在研究的哥伦比亚人群中，SpA 患者与健康对照组的 TNF-α-308SNP 基因型频率存在差异。此外，与活性和功能临床指数、血清 TNF-α 水平或 HLA B27 状态无显著相关性。另一方面，等位基因频率与临床活动指数相关。
