使用 2450-MHz 冷轴微波天线比较不同组织的消融区域：在离体猪模型中的结果。
Comparison of ablation zones among different tissues using 2450-MHz cooled-shaft microwave antenna: results in ex vivo porcine models.
机构信息
Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
出版信息
PLoS One. 2013 Aug 12;8(8):e71873. doi: 10.1371/journal.pone.0071873. eCollection 2013.
BACKGROUND
For complete tumor ablation in different tissues, it is necessary to investigate the exact coagulation zone of microwave ablation in different tissues. The aim of this study was to compare the extent of microwave ablation zone in muscle, liver and adipose tissue in ex vivo porcine models and assess the shape of microwave coagulation zone among these tissues.
MATERIALS AND METHODS
Microwave ablations were performed in ex vivo porcine muscle, liver and adipose tissue using 2450-MHz cooled-shaft microwave antenna. The content of water, fat and protein in these three tissues was determined. Two power increments (40 and 80 W) and five time increments (1, 3, 5, 7, and 10 minutes) were used in this study. Diameters and shapes of the ablation zones were assessed on gross specimens.
RESULTS
The average percentages of water, fat and protein in these three tissues were significantly different (P < 0.001), respectively. The long-axis and short-axis diameters among these three tissues at each time-power combination were not significantly different (P > 0.05). The coagulation zones were all elliptical in muscle, liver and adipose tissue. When microwave ablation was performed in the tissue containing both muscle and adipose tissue, the coagulation zone was also elliptical. Regardless of the output power, the ellipticity index (EI) value of 1 minute treatment duration was higher than that of 10 minutes treatment duration (P < 0.05). Furthermore, the EI value did not decrease significantly when the treatment duration was more than 5 minutes (P > 0.05).
CONCLUSION
The extent of microwave ablation zones was not significantly different among completely different tissues. Microwave ablations with ≥ 5 minutes time duration can induce coagulation zones with clinical desirable shape. Future clinical studies are still required to determine the role of microwave ablation in different tissues.
背景
为了实现不同组织的完全肿瘤消融，有必要研究不同组织中微波消融的确切凝固区。本研究旨在比较离体猪模型中肌肉、肝脏和脂肪组织中微波消融区的范围，并评估这些组织中微波凝固区的形状。
材料与方法
使用 2450MHz 冷轴微波天线在离体猪肌肉、肝脏和脂肪组织中进行微波消融。测定这三种组织的水分、脂肪和蛋白质含量。本研究采用两种功率增量（40 和 80W）和五种时间增量（1、3、5、7 和 10 分钟）。在大体标本上评估消融区的直径和形状。
结果
这三种组织的水分、脂肪和蛋白质平均百分比差异有统计学意义（P<0.001）。在每个时间-功率组合中，这三种组织的长轴和短轴直径差异无统计学意义（P>0.05）。在肌肉、肝脏和脂肪组织中，凝固区均呈椭圆形。当在含有肌肉和脂肪组织的组织中进行微波消融时，凝固区也是椭圆形的。无论输出功率如何，1 分钟治疗持续时间的椭圆率指数（EI）值均高于 10 分钟治疗持续时间（P<0.05）。此外，当治疗时间超过 5 分钟时，EI 值没有显著降低（P>0.05）。
结论
完全不同的组织中微波消融区的范围没有显著差异。治疗时间≥5 分钟可产生具有临床理想形状的凝固区。仍需要未来的临床研究来确定微波消融在不同组织中的作用。
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