Del Rio Paolo, Crafa Pellegrino, Papadia Cinzia, Benecchi Laura, Campanini Nicoletta, Sianesi Nicoletta, Montana Chiara Montana, Sianesi Mario
Department of Surgical Science, General Surgery and Organ Transplantation, University Hospital of Parma, Parma, Italy.
Ann Ital Chir. 2011 Jul-Aug;82(4):279-82.
Previous studies reported that CD10 positive Colorectal Cancer Cells (CRC) characterized by deeply invasive neoplasia.
We have examined 50 pts surgically treated for colorectal cancer on at least 5 years follow up. TNM, grading score and survival have been compared to CD10 expression.
Thirty-four out of fifty cases have been analyzed (18 males and 16 female) of whom nineteen were CD10 positive and fifteen were CD10 negative. The remaining 16 cases were droping out. No difference in survival rate between CD10 positive and negative in N0, N1, N2. No difference on survival rate and grading 1, 2, 3. We have then analyzed CD10 positive and CD10 negative cases, according to neoplasia grading, in patients with positive linphonodes N1 and N2. We showed a statistical difference between the CD10 positive/N2 (grading 1.66 +/- 0.5) and the CD10 negative/N2 (grading 3) (p < 0.005).
We can hypothesize that CD10 positive neoplasia display a more invasive behaviour, independently from the N score and the G score, compared to CD10 negative neoplasia.
先前的研究报道，以深度浸润性肿瘤为特征的结直肠癌细胞（CRC）CD10呈阳性。
我们对50例接受手术治疗的结直肠癌患者进行了至少5年的随访。将TNM、分级评分和生存率与CD10表达进行了比较。
分析了50例中的34例（18例男性和16例女性），其中19例CD10阳性，15例CD10阴性。其余16例失访。在N0、N1、N2中，CD10阳性和阴性患者的生存率无差异。在1级、2级、3级患者的生存率和分级方面也无差异。然后，我们根据肿瘤分级，对N1和N2阳性淋巴结患者的CD10阳性和CD10阴性病例进行了分析。我们发现CD10阳性/N2（分级1.66±0.5）和CD10阴性/N2（分级3）之间存在统计学差异（p<0.005）。
我们可以推测，与CD10阴性肿瘤相比，CD10阳性肿瘤表现出更强的侵袭行为，与N评分和G评分无关。
