Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Org Lett. 2011 Sep 2;13(17):4676-9. doi: 10.1021/ol201895s. Epub 2011 Aug 11.
A 1,10-phenanthroline-ligated cationic silver complex allows the intramolecular chloroamination of allenes with N-chlorosuccinimide using 2,6-lutidine as a base. This process proceeds under mild conditions and can tolerate a variety of functional groups. The chloroamination products are useful synthetic intermediates and can be easily transformed into functionalized 3-pyrroline and pyrrole derivatives.
一种 1,10-菲咯啉配体的阳离子银配合物允许使用 N-氯代丁二酰亚胺和 2,6- 二甲基吡啶作为碱，将烯丙基化合物进行分子内氯胺化反应。这个过程在温和的条件下进行，可以容忍多种官能团。氯胺化产物是有用的合成中间体，并且可以很容易地转化为官能化的 3-吡咯啉和吡咯衍生物。
