银催化的活化丙二烯的分子内氨基氟化反应。
Silver-catalyzed intramolecular aminofluorination of activated allenes.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
出版信息
Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8176-9. doi: 10.1002/anie.201103225. Epub 2011 Jul 14.
PMID:21761534
Abstract
A nice combination: the intramolecular oxidative aminofluorination of allenes using silver catalysis and FN(SO(2)Ph)(2) as the fluorinating reagent has been developed. This reaction represents an efficient method for the synthesis of various 4-fluoro-2,5-dihydropyrrole compounds. Further transformation provided the corresponding fluorinated pyrrole derivatives in good yields.
摘要
一种很好的组合
使用银催化和 FN(SO(2)Ph)(2)作为氟源，实现了丙二烯的分子内氧化氨氟化反应。该反应为合成各种 4-氟-2,5-二氢吡咯化合物提供了一种有效的方法。进一步的转化以良好的收率得到了相应的氟化吡咯衍生物。
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