Gabbay-Benziv Rinat, Yogev Yariv, Melamed Nir, Ben-Haroush Avi, Meizner Israel, Pardo Joseph
J Matern Fetal Neonatal Med. 2012 Jun;25(6):666-8. doi: 10.3109/14767058.2011.594119. Epub 2011 Aug 11.
To evaluate pregnancy outcome following late amniocentesis (>24 weeks of gestation).
A retrospective cohort of all women with singleton pregnancy that underwent late amniocentesis in one tertiary center.
Pregnancy outcome was validated in 168 women who underwent late amniocentesis. Overall, for the all study group the mean gestational age for amniocentesis was 31.6 ± 2.3 weeks and the mean gestational age at delivery was 38.1 ± 2. Indications for late amniocentesis included abnormal ultrasonographic findings (n = 120), suspected intrauterine infection (n = 23), advanced maternal age (n = 13), abnormal first or second trimester biochemical markers (n = 8) and others. The overall rate of spontaneous preterm delivery (<37 weeks) was 8% (13/168) with mean gestational age at delivery of 34.7 ± 1.3. In only five cases (3%), delivery occurred ≤ 34 weeks of gestation. In one case (0.60%) of amniocentesis performed at 32 weeks of gestation, delivery occurred within 48 hours and in other four cases (2.40%) delivery occurred within 10 days. When amniocentesis was performed due to ultrasonographic findings to rule out chromosomal abnormalities (n = 117/182), abnormal karyotype was found only in three cases.
The risk of significant prematurity following late amniocentesis is low. This information is important when counseling patients considering performing one.
评估妊娠晚期（妊娠>24周）羊膜腔穿刺术后的妊娠结局。
对在一家三级医疗中心接受妊娠晚期羊膜腔穿刺术的所有单胎妊娠女性进行回顾性队列研究。
168例行妊娠晚期羊膜腔穿刺术的女性的妊娠结局得到验证。总体而言，所有研究组羊膜腔穿刺术时的平均孕周为31.6±2.3周，分娩时的平均孕周为38.1±2周。妊娠晚期羊膜腔穿刺术的指征包括超声检查结果异常（n = 120）、疑似宫内感染（n = 23）、产妇年龄较大（n = 13）、孕早期或孕中期生化指标异常（n = 8）及其他情况。自然早产（<37周）的总体发生率为8%（13/168），分娩时的平均孕周为34.7±1.3周。仅5例（3%）在妊娠≤34周时分娩。在1例（0.60%）妊娠32周时进行的羊膜腔穿刺术中，在48小时内分娩，其他4例（2.40%）在10天内分娩。当因超声检查结果行羊膜腔穿刺术以排除染色体异常时（n = 117/182），仅3例发现异常核型。
妊娠晚期羊膜腔穿刺术后发生严重早产的风险较低。这一信息在为考虑进行该操作的患者提供咨询时很重要。
