Ciach Katarzyna, Preis Krzysztof, Swiatkowska-Freund Małgorzata, Wydra Dariusz
Katedra Perinatologii Klinika Połoznictwa AM w Gdańsku.
Ginekol Pol. 2008 Jan;79(1):12-6.
The demand for genetic amniocentesis in case of young pregnant women has significantly increased due to various new indications. Moreover, nowadays a growing number of women aged > or =35, who required genetic amniocentesis, get pregnant The aim of the following study has been to compare the course of the pregnancy, the delivery and the condition of the newborn in two groups of patients: 18-34 years old and > or =35 years old.
783 women underwent the procedure of amniocentesis at the Department of Obstetrics of Medical University of Gdansk in 1996-2003. A group of 540 women, who answered the questionnaire about the course of the pregnancy and the delivery after the procedure, has been isolated.
Fetal loss occurred in 2 cases (1.6%) in the group of the younger women and in 8 cases (0.8%) in the group of > or =35 year-olds (p=0.84). There was no statistically significant difference between younger and older patients when comparing complications after the procedure in the first three weeks following amniocentesis: spotting, bleeding, leakage of amniotic fluid. Frequency of late complications such as gestational diabetes mellitus, pregnancy induced hypertension and urinary tract infections were comparable in both age groups women. Cesarean section has been more frequently performed in case of the older women than in the group of younger patients, with statistical difference p=0.003. In most cases (33.9%) it has been an elective cesarean section, performed due to advanced maternal age rather than any obstetric cause. Frequency of pneumonia and the number of respiratory infections in the newborns have been comparable in both groups.
Prenatal invasive diagnosis has no influence on frequency of complications during pregnancy and delivery in the group of women less than 35 years old and more than 35 years old.
由于各种新的适应症，年轻孕妇对遗传羊膜穿刺术的需求显著增加。此外，如今越来越多需要遗传羊膜穿刺术的35岁及以上女性怀孕了。以下研究的目的是比较两组患者（18 - 34岁和35岁及以上）的妊娠过程、分娩情况和新生儿状况。
1996 - 2003年，783名女性在格但斯克医科大学妇产科接受了羊膜穿刺术。其中540名女性回答了关于术后妊娠过程和分娩情况的问卷，组成了一个研究组。
年轻女性组有2例（1.6%）发生胎儿丢失，35岁及以上女性组有8例（0.8%）发生胎儿丢失（p = 0.84）。在比较羊膜穿刺术后前三周的并发症（点滴出血、出血、羊水渗漏）时，年轻患者和年长患者之间无统计学显著差异。两组女性中妊娠糖尿病、妊娠高血压和尿路感染等晚期并发症的发生率相当。年长女性剖宫产的频率高于年轻患者组，差异有统计学意义（p = 0.003）。在大多数情况下（33.9%），剖宫产是选择性剖宫产，原因是产妇年龄较大而非任何产科原因。两组新生儿肺炎的发生率和呼吸道感染的次数相当。
产前侵入性诊断对35岁以下和35岁以上女性妊娠和分娩期间并发症的发生率没有影响。
