School of Electrical Engineering and Computer Science, Kyungpook National University, Daegu 702-701, Republic of Korea.
Biosens Bioelectron. 2011 Oct 15;28(1):434-7. doi: 10.1016/j.bios.2011.07.062. Epub 2011 Jul 30.
In this study, we propose a novel biosensor based on a gated lateral bipolar junction transistor (BJT) for biomaterial detection. The gated lateral BJT can function as both a BJT and a metal-oxide-semiconductor field-effect transistor (MOSFET) with both the emitter and source, and the collector and drain, coupled. C-reactive protein (CRP), which is an important disease marker in clinical examinations, can be detected using the proposed device. In the MOSFET-BJT hybrid mode, the sensitivity, selectivity, and reproducibility of the gated lateral BJT for biosensors were evaluated in this study. According to the results, in the MOSFET-BJT hybrid mode, the gated lateral BJT shows good selectivity and reproducibility. Changes in the emitter (source) current of the device for CRP antigen detection were approximately 0.65, 0.72, and 0.80 μA/decade at base currents of -50, -30, and -10 μA, respectively. The proposed device has significant application in the detection of certain biomaterials that require a dilution process using a common biosensor, such as a MOSFET-based biosensor.
在这项研究中，我们提出了一种基于门控横向双极结晶体管（BJT）的新型生物传感器，用于生物材料检测。门控横向 BJT 可以同时作为 BJT 和金属氧化物半导体场效应晶体管（MOSFET）工作，其发射极和源极以及集电极和漏极相互耦合。C-反应蛋白（CRP）是临床检查中的一个重要疾病标志物，可以使用所提出的设备进行检测。在 MOSFET-BJT 混合模式下，本研究评估了门控横向 BJT 对生物传感器的灵敏度、选择性和重现性。结果表明，在 MOSFET-BJT 混合模式下，门控横向 BJT 具有良好的选择性和重现性。在基极电流分别为-50、-30 和-10 μA 时，CRP 抗原检测器件的发射极（源极）电流变化约为 0.65、0.72 和 0.80 μA/decade。该设备在检测某些需要使用常见生物传感器（如基于 MOSFET 的生物传感器）进行稀释处理的生物材料方面具有重要的应用。
