多焦视网膜电图在色素性视网膜炎中的主成分分析。

Principal components' analysis of multifocal electroretinogram in retinitis pigmentosa.

机构信息

Department of Vitreo-Retinal Services, Aditya Jyot Eye Hospital Pvt Ltd, Plot No: 153, Road No 9, Major Parmeswaran Road, Wadala, Mumbai - 400 031, India.

出版信息

Indian J Ophthalmol. 2011 Sep-Oct;59(5):353-7. doi: 10.4103/0301-4738.83610.

DOI:10.4103/0301-4738.83610

PMID:21836339

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3159315/

Abstract

AIMS

To determine waveforms of multifocal electroretinogram (mfERG) in patients with retinitis pigmentosa (RP) contributing significantly to the overall retinal response by using principal components' analysis.

SETTINGS AND DESIGN

Prospective, non-randomized, single-visit, observational, case-control study from a single tertiary ophthalmic center.

MATERIALS AND METHODS

Patients with various forms of RP underwent mfERG testing for a period of one year. The first-order kernel responses of RP cases were compared with concurrently recruited healthy controls.

STATISTICAL ANALYSIS USED

Parametric data was analyzed using the unpaired t test for differences between the implicit time and amplitudes of cases and controls. Principal components' analysis was done for each implicit time and amplitude in cases with RP using the Varimax rotation method.

RESULTS

From March 2006 to March 2007, 24 cases with typical RP (56%, 47 eyes) were included in the final analysis. Their mean age was 33.7 years (19-69 ± 15.5 years). Comparison of latencies and amplitudes among RP cases with log MAR acuity ≤ 0.18 and those > 0.18, revealed significant difference in the implicit time (P1) in Ring 2 only (P=0.028). Two components (predominently from Ring 1 and 2) each contributing 66.8% and 88.8% of the total variance in the data for latencies and amplitudes respectively, were seen.

CONCLUSIONS

The first two rings of the mfERG contributed to the variance of waveforms in RP, irrespective of the visual acuity and poor visual field results.

摘要

目的

通过主成分分析确定对视网膜整体反应贡献较大的色素性视网膜炎（RP）患者多焦视网膜电图（mfERG）的波形。

设置和设计

来自单一三级眼科中心的前瞻性、非随机、单次就诊、观察性、病例对照研究。

材料和方法

在为期一年的时间里，各种形式的 RP 患者接受 mfERG 测试。将 RP 病例的一阶核反应与同时招募的健康对照组进行比较。

使用的统计分析

对病例和对照组的潜伏期和振幅之间的差异使用配对 t 检验进行参数数据分析。使用 Varimax 旋转方法对 RP 病例的每个潜伏期和振幅进行主成分分析。

结果

从 2006 年 3 月到 2007 年 3 月，最终分析中包括 24 例典型 RP（56%，47 只眼）。他们的平均年龄为 33.7 岁（19-69 ± 15.5 岁）。对 logMAR 视力≤0.18 和>0.18 的 RP 病例的潜伏期和振幅进行比较，仅在环 2 中发现潜伏期（P1）有显著差异（P=0.028）。两个成分（主要来自环 1 和 2）分别对潜伏期和振幅数据的总方差贡献 66.8%和 88.8%。