Demetris A J, Qian S G, Sun H, Fung J J
Department of Pathology, Presbyterian University Hospital, Pittsburgh, PA 15213.
Am J Surg Pathol. 1990;14 Suppl 1:49-63.
Recent improvements in patient survival has resulted in widespread use of liver transplantation as therapy for end stage liver disease. The pathologist plays a critical role in the pre- and post-operative care of these patients, and the core needle biopsy of the allograft has become a fairly reliable method of diagnosing acute cellular rejection. Most of the non-rejection related causes of graft dysfunction produce morphologic manifestations similar to those seen in nontransplanted livers (e.g., duct obstruction resembles duct obstruction). Many pathologists are, however, unfamiliar with the histologic changes of the various types of rejection. The following article is an attempt to acquaint pathologists with the morphologic features of liver allograft rejection. As a backdrop to understanding the events in humans, observations in untreated experimental animals are presented and reviewed briefly.
近年来患者生存率的提高使得肝移植作为终末期肝病的治疗方法得到广泛应用。病理学家在这些患者的术前和术后护理中发挥着关键作用，同种异体移植物的核心针吸活检已成为诊断急性细胞排斥反应相当可靠的方法。大多数与排斥反应无关的移植物功能障碍原因产生的形态学表现与非移植肝脏中所见的相似（例如，胆管梗阻类似于胆管梗阻）。然而，许多病理学家并不熟悉各种类型排斥反应的组织学变化。以下文章旨在使病理学家熟悉肝同种异体移植排斥反应的形态学特征。作为理解人类事件的背景，简要介绍并回顾了未经治疗的实验动物的观察结果。
