Hassanein T I, Gavaler J S, Fishkin D, Gordon R, Starzl T E, Van Thiel D H
Division of Gastroenterology, University of Pittsburgh, School of Medicine, Pennsylvania 15213.
Alcohol Clin Exp Res. 1991 Mar;15(2):300-3. doi: 10.1111/j.1530-0277.1991.tb01873.x.
The widespread application of hepatic transplantation has created a tremendous demand for donor organs. An assessment of donor parameters is thought to be important in selecting good donors; however, the criteria utilized have not been standardized. This study was performed to determine the effect of a measurable donor blood alcohol level on graft survival. Fifty-two patients who underwent orthotopic liver transplantation at the University of Pittsburgh were included in the study. Twenty-five patients received liver grafts from donors having a blood alcohol level between 0.04 and 0.4 g/l with a mean of 0.17 g/l. Twenty-seven patients received a liver graft from a donor who had no measurable blood alcohol. There were no differences between these two groups of donors regarding the time of initial hospitalization until the time of donation. Graft failure within the first 30 days was 24% for those receiving an organ from an alcohol-positive donor as compared with 22.2% in those receiving an organ from an alcohol negative donor. The recipient mortality rate was 16% and 11%, respectively. No relationships between the donor blood alcohol level and organ performance, frequency of primary graft nonfunction, or number of episodes of acute cellular rejection were evident. Based upon these data, the presence of a measurable blood alcohol level in a donor should not mitigate against organ donation.
肝移植的广泛应用产生了对供体器官的巨大需求。评估供体参数在选择优质供体方面被认为很重要；然而，所采用的标准尚未标准化。本研究旨在确定可测量的供体血液酒精水平对移植物存活的影响。匹兹堡大学接受原位肝移植的52例患者被纳入研究。25例患者接受了血液酒精水平在0.04至0.4 g/l之间、平均为0.17 g/l的供体的肝脏移植。27例患者接受了无可测量血液酒精的供体的肝脏移植。这两组供体在初次住院至捐献期间的时间方面没有差异。接受酒精阳性供体器官的患者在术后30天内的移植物失败率为24%，而接受酒精阴性供体器官的患者为22.2%。受体死亡率分别为16%和11%。供体血液酒精水平与器官性能、原发性移植物无功能频率或急性细胞排斥发作次数之间没有明显关系。基于这些数据，供体中存在可测量的血液酒精水平不应成为器官捐献的阻碍。
