通过催化不对称转移氢化喹啉，直接对映选择性地获得 4-取代的四氢喹啉。
Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg, 1, D-52074, Aachen, Germany. Magnus,
出版信息
Org Biomol Chem. 2011 Oct 7;9(19):6844-50. doi: 10.1039/c1ob05870c. Epub 2011 Aug 12.
PMID:21837348
Abstract
A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.
摘要
已开发出一种方便的对映选择性合成 4-取代四氢喹啉的方法。手性 BINOL 磷酸促进了广泛的 4-取代喹啉与 Hantzsch 酯的还原反应，具有良好到高的对映选择性。
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