Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3508GA, Postbus 85500, Utrecht, The Netherlands.
Eur Radiol. 2012 Jan;22(1):120-8. doi: 10.1007/s00330-011-2237-9. Epub 2011 Aug 12.
To determine the relationship between lung function impairment and quantitative computed tomography (CT) measurements of air trapping and emphysema in a population of current and former heavy smokers with and without airflow limitation.
In 248 subjects (50 normal smokers; 50 mild obstruction; 50 moderate obstruction; 50 severe obstruction; 48 very severe obstruction) CT emphysema and CT air trapping were quantified on paired inspiratory and end-expiratory CT examinations using several available quantification methods. CT measurements were related to lung function (FEV(1), FEV(1)/FVC, RV/TLC, Kco) by univariate and multivariate linear regression analysis.
Quantitative CT measurements of emphysema and air trapping were strongly correlated to airflow limitation (univariate r-squared up to 0.72, p < 0.001). In multivariate analysis, the combination of CT emphysema and CT air trapping explained 68-83% of the variability in airflow limitation in subjects covering the total range of airflow limitation (p < 0.001).
The combination of quantitative CT air trapping and emphysema measurements is strongly associated with lung function impairment in current and former heavy smokers with a wide range of airflow limitation.
在有和无气流受限的当前和既往重度吸烟者人群中，确定肺功能损害与空气潴留和肺气肿的定量计算机断层扫描（CT）测量之间的关系。
在 248 名受试者（50 名正常吸烟者；50 名轻度阻塞；50 名中度阻塞；50 名重度阻塞；48 名非常严重阻塞）中，使用几种可用的定量方法，在吸气和呼气末 CT 检查上对 CT 肺气肿和 CT 空气潴留进行定量。通过单变量和多变量线性回归分析，将 CT 测量值与肺功能（FEV1、FEV1/FVC、RV/TLC、Kco）相关联。
肺气肿和空气潴留的定量 CT 测量值与气流受限呈强相关（单变量 r 平方高达 0.72，p<0.001）。在多变量分析中，CT 肺气肿和 CT 空气潴留的组合解释了气流受限范围很广的当前和既往重度吸烟者中气流受限变化的 68-83%（p<0.001）。
定量 CT 空气潴留和肺气肿测量值的组合与当前和既往重度吸烟者的肺功能损害密切相关，其气流受限范围很广。
