Department of Internal Medicine, University of Zurich, Zurich, Switzerland.
Infection. 2012 Apr;40(2):203-5. doi: 10.1007/s15010-011-0174-9. Epub 2011 Aug 12.
Our case illustrates the difficulties involved in diagnosing multicentric Castleman's disease (MCD) in a human immunodeficiency virus-infected man with febrile episodes and malaise. In the absence of well-established treatment protocols, we have chosen a new treatment algorithm with rituximab, etoposide, and valganciclovir, which led to the remission of clinical symptoms. Yet, we advocate focused exploration for MCD in immunosuppressed patients with unclear febrile episodes, as recent advances in treatment are promising.
我们的病例说明了在一名感染人类免疫缺陷病毒（HIV）、有发热和不适症状的患者中诊断多中心Castleman 病（MCD）的困难。由于缺乏既定的治疗方案，我们选择了一种新的治疗方案，即利妥昔单抗、依托泊苷和缬更昔洛韦，这导致了临床症状的缓解。然而，我们主张在发热原因不明的免疫抑制患者中对 MCD 进行有针对性的探索，因为最近的治疗进展很有前景。
