Song Jia, Ouyang Tian-xiang, Huang Ying-ying, Liu Jun, Xiao Yan, Chen Hui-ping, Yu Jie
Department of Plastic Surgery, Xinhua Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2011 May;27(3):178-81.
To distinguish non involuting congenital hemangioma (NICH) and infantile hemangioma (IH) by comparing the pathological structure and marker antigen expression.
From Jan. 2005 to Aug. 2010, 39 paraffin-embedded samples, including 13 cases of NICH, 13 cases of proliferating IH and 13 cases of involuting IH, were collected from operation. Hematoxylin-eosin staining was used to observe the pathological structure. Immunohistochemical analysis was also performed to investigate the expression of Glut-1.
The lobules of capillaries were well-defined in NICH. The lobules were surrounded by abundant fibrous tissue. The capillaries were often large and integrity in NICH. There were few mitosis and apoptosis in endothelial cells and stromal cells in NICH. While in IH, the pathologic findings were totally different. Immunochemistry revealed that the Glut-1 was expressed in endothelial cells of IH, but not in NICH.
NICH has a steady histologic structure and low proliferation, while the endothelial cells in proliferative IH has a high proliferation. Glut-1 can be used as the reliable marker antigen for differential diagnosis of NICH and proliferative infantile hemangiomas.
通过比较非消退性先天性血管瘤（NICH）和婴儿血管瘤（IH）的病理结构及标记抗原表达来进行鉴别。
收集2005年1月至2010年8月手术切除的39例石蜡包埋样本，其中包括13例NICH、13例增殖期IH和13例消退期IH。采用苏木精-伊红染色观察病理结构，同时进行免疫组化分析检测Glut-1的表达。
NICH中毛细血管小叶界限清晰，小叶被丰富的纤维组织包绕，毛细血管通常较大且完整，内皮细胞和间质细胞中少见有丝分裂和凋亡。而在IH中，病理表现完全不同。免疫组化显示Glut-1在IH的内皮细胞中表达，而在NICH中不表达。
NICH组织结构稳定、增殖性低，而增殖期IH的内皮细胞增殖性高。Glut-1可作为鉴别NICH和增殖期婴儿血管瘤的可靠标记抗原。
