Hayward Reid, Lien Chia-Ying
School of Sport and Exercise Science, University of Northern Colorado, Greeley, Colorado, USA.
J Am Assoc Lab Anim Sci. 2011 Jul;50(4):454-61.
Echocardiography is a widely used evaluation tool in cardiovascular research. Although rats are a common model in such research, normal echocardiographic values for young, developing rats have not been established. Furthermore, whether exercise during the developmental phase of the lifespan affects the structure or function of the heart is unclear. Male Sprague-Dawley rat pups (21 d) were assigned randomly to a nonexercise or voluntary exercise group for 12 wk. Echocardiograms were obtained before and at weekly intervals during the 12-wk observation period. Maturation resulted in changes in many echocardiographically derived variables, whereas voluntary exercise failed to alter the development of cardiac structure or function. This study provides normal echocardiographic variables for developing male rats and provides evidence that exercise during the developmental phase of the lifespan has little effect on cardiac morphology and function as assessed by echocardiography.
超声心动图是心血管研究中广泛使用的评估工具。虽然大鼠是此类研究中的常见模型，但尚未确立幼年发育中大鼠的正常超声心动图值。此外，在寿命的发育阶段进行运动是否会影响心脏的结构或功能尚不清楚。将雄性斯普拉格-道利大鼠幼崽（21日龄）随机分为非运动组或自愿运动组，为期12周。在12周的观察期内，在实验开始前及每周获取超声心动图。成熟导致许多超声心动图衍生变量发生变化，而自愿运动未能改变心脏结构或功能的发育。本研究提供了发育中雄性大鼠的正常超声心动图变量，并提供证据表明，在寿命的发育阶段进行运动对超声心动图评估的心脏形态和功能影响很小。
