Mankaï A, Achour A, Thabet Y, Manoubia W, Sakly W, Ghedira I
Research Unit (03UR/07-02), Faculty of Pharmacy, Monastir, Tunisia.
Pathol Biol (Paris). 2012 Oct;60(5):291-5. doi: 10.1016/j.patbio.2011.07.003. Epub 2011 Aug 11.
To determine the frequency of anti-cardiolipin (aCL) and anti-β2-glycoprotein I antibodies (aβ2GPI) in celiac disease (CD) patients.
Sixty-three untreated CD patients and 40 healthy blood donors (HBD) were studied. IgG, IgA and IgM aCL and aβ2GPI were detected by Elisa.
The frequency of antiphospholipid antibodies (aPL) (aCL and/or aβ2GPI) was significantly higher in CD patients (12 out of 63) than in HBD (two out of 40) (19% vs 5%, P=0.04). Six CD patients out of 63 (9.5%) and one HBD out of 40 (2.5%) had aCL. Ten CD patients (15.9%) and two HBD (5%) had aβ2GPI. Only aβ2GPI-IgA was significantly more frequent in CD patients than in HBD (14.3% vs 2.5%, P=0.048). In CD patients, aβ2GPI-IgA (nine out of 63) was significantly more frequent (14.3%) than aβ2GPI-IgG (1.6%) and IgM (1.6%) (P=0.008). In CD patients, the frequency of aCL-IgA and IgM was 6.3% (four out of 63) and aCL-IgG were not detected. Simultaneous presence of positive antibodies was found in four CD patients: one patient had four aPL, one had three aPL and two had two aPL. The four patients who had aCL-IgA had also aβ2GPI-IgA and three of them had a titer higher than 50 units. Among nine patients with aβ2GPI-IgA, four had a titer higher than 100 units. The highest titers were found in adults.
aPL and particularly aβ2GPI-IgA are frequent in CD. The significance of these antibodies has to be determined.
确定乳糜泻（CD）患者中抗心磷脂（aCL）和抗β2糖蛋白I抗体（aβ2GPI）的出现频率。
研究了63例未经治疗的CD患者和40名健康献血者（HBD）。通过酶联免疫吸附测定法（ELISA）检测IgG、IgA和IgM型aCL和aβ2GPI。
CD患者中抗磷脂抗体（aPL，aCL和/或aβ2GPI）的出现频率（63例中有12例）显著高于HBD（40例中有2例）（19%对5%，P = 0.04）。63例CD患者中有6例（9.5%）和40名HBD中有1例（2.5%）有aCL。10例CD患者（15.9%）和2名HBD（5%）有aβ2GPI。仅aβ2GPI-IgA在CD患者中的出现频率显著高于HBD（14.3%对2.5%，P = 0.048）。在CD患者中，aβ2GPI-IgA（63例中有9例）的出现频率（14.3%）显著高于aβ2GPI-IgG（1.6%）和IgM（1.6%）（P = 0.008）。在CD患者中，aCL-IgA和IgM的出现频率为6.3%（63例中有4例），未检测到aCL-IgG。4例CD患者同时存在阳性抗体：1例患者有4种aPL，1例有3种aPL，2例有2种aPL。有aCL-IgA的4例患者也有aβ2GPI-IgA，其中3例滴度高于50单位。在9例有aβ2GPI-IgA的患者中，4例滴度高于100单位。最高滴度出现在成年人中。
aPL尤其是aβ2GPI-IgA在CD中很常见。这些抗体的意义有待确定。
