Azarsiz Elif, Eman Gamze, Akarcan Sanem Eren, Severcan Ezgi Ulusoy, Karaca Neslihan, Aksu Guzide, Kutukculer Necil
Department of Pediatric Immunology, Faculty of Medicine, Ege University, 35040 Bornova, Izmir, Turkey.
Indian J Clin Biochem. 2019 Jan;34(1):95-100. doi: 10.1007/s12291-017-0711-0. Epub 2017 Nov 10.
Anti-beta-2-glycoprotein I antibodies (anti-β2GPI) which are the main antiphospholipid antibodies that characterize the autoimmune "antiphospholipid syndrome" are pathogenic and are contributing to thrombosis. We aimed to evaluate the presence and the diagnostic importance of these antibodies in children with different rheumatologic diseases with or without thrombosis risk. A total of 100 children with different rheumatologic diseases evaluated retrospectively. The mean anti-β2GPI IgG ( = 0.108), IgA ( = 0.547), and IgM ( = 0.807) levels showed no statistically significant difference between different diagnosis groups. But anti-β2GPI IgA and IgM levels were higher in SLE patient group. The mean anti-β2GPI IgG ( = 0.375), IgA ( = 0.811), and IgM ( = 0.276) levels were not also showed difference between disease groups with/without predisposition to thrombosis even though concentrations were higher in thrombosis group. In children with rheumatological complaints, anti-β2GPI antibody measurements should not be the first diagnostic criteria if vasculitis is not thought as the primary defect underlying the clinical symptoms.
抗β2糖蛋白I抗体（抗β2GPI）是自身免疫性“抗磷脂综合征”的主要抗磷脂抗体，具有致病性且会导致血栓形成。我们旨在评估这些抗体在有或无血栓形成风险的不同风湿性疾病患儿中的存在情况及其诊断重要性。对100例患有不同风湿性疾病的患儿进行回顾性评估。不同诊断组之间抗β2GPI IgG（=0.108）、IgA（=0.547）和IgM（=0.807）的平均水平无统计学显著差异。但系统性红斑狼疮（SLE）患者组中抗β2GPI IgA和IgM水平较高。有/无血栓形成倾向的疾病组之间，抗β2GPI IgG（=0.375）、IgA（=0.811）和IgM（=0.276）的平均水平也无差异，尽管血栓形成组中的浓度较高。对于有风湿性症状的患儿，如果不认为血管炎是临床症状的主要潜在缺陷，抗β2GPI抗体检测不应作为首要诊断标准。
