Colomer Claude, Martin Agnès O, Desarménien Michel G, Guérineau Nathalie C
Institut de Génomique Fonctionnelle, F-34000 Montpellier, France.
Biochim Biophys Acta. 2012 Aug;1818(8):1937-51. doi: 10.1016/j.bbamem.2011.07.034. Epub 2011 Jul 31.
The traditional understanding of stimulus-secretion coupling in adrenal neuroendocrine chromaffin cells states that catecholamines are released upon trans-synaptic sympathetic stimulation mediated by acetylcholine released from the splanchnic nerve terminals. Although this statement remains largely true, it deserves to be tempered. In addition to its neurogenic control, catecholamine secretion also depends on a local gap junction-mediated communication between chromaffin cells. We review here the insights gained since the first description of gap junctions in the adrenal medullary tissue. Adrenal stimulus-secretion coupling now appears far more intricate than was previously envisioned and its deciphering represents a challenge for neurobiologists engaged in the study of the regulation of neuroendocrine secretion. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics.
传统观点认为，肾上腺神经内分泌嗜铬细胞中的刺激-分泌偶联是指在内脏神经末梢释放的乙酰胆碱介导的跨突触交感神经刺激下，儿茶酚胺得以释放。尽管这一说法在很大程度上仍然正确，但也需要加以修正。除了神经源性控制外，儿茶酚胺的分泌还依赖于嗜铬细胞之间局部的缝隙连接介导的通讯。在此，我们回顾自首次描述肾上腺髓质组织中的缝隙连接以来所获得的见解。现在看来，肾上腺刺激-分泌偶联远比之前设想的更为复杂，其解析对于从事神经内分泌分泌调节研究的神经生物学家而言是一项挑战。本文是名为《通讯连接、组成、结构和特性》的特刊的一部分。
