Brandão Cristina Mariano Ruas, Guerra Augusto Afonso, Cherchiglia Mariângela Leal, Andrade Eli Iola Gurgel, Almeida Alessandra Maciel, da Silva Grazielle Dias, de Queiroz Odilon Vanni, Faleiros Daniel Resende, Acurcio Francisco de Assis
Programa de Pós-graduação em Saúde Pública da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Value Health. 2011 Jul-Aug;14(5 Suppl 1):S71-7. doi: 10.1016/j.jval.2011.05.028.
To describe the expenses of the Ministry of Health of Brazil with users of High-Cost Drug Program that began treatment between 2000-2004, according to their demographic and clinical characteristics.
We made a probabilistic-deterministic linkage of national databases of drugs and mortality, resulting in a historical cohort of patients using high-cost medications in 2000-2004. The per capita spending on medicines were stratified by a follow-up period and described according to demographic, clinical and type of drug used.
The total population atended by the program was 611,419, being 63.5% female, average age 46 years. 41.9% of patients living in the Southeast and 29.7% in the Northeast of Brazil. 24.5% of patients began treatment in 2000, 12.4% in 2001, with increasing trend until 2004. The most prevalent diagnosis referred to the genitourinary system diseases and the most common use of chemical groups were antianemic preparations. 40,941 deaths were detected (6.7% of total). The total expenditure per capita was R$4.794,34. Higher spending per capita was observed in males, aged 47, who lived in the Southeast of Brazil and began treatment in 2000, had diagnoses of infectious and parasitic diseases and used blood substitutes and perfusions solutions.
The understanding of the expenses involved subsidizes restructuring actions and scheduling drug programs, also provides information for therapeutic groups which are priorities for analysis.
根据巴西卫生部针对2000年至2004年间开始接受治疗的高成本药物项目使用者的人口统计学和临床特征，描述其费用情况。
我们对国家药物数据库和死亡率数据库进行了概率确定性关联，从而形成了一个2000年至2004年间使用高成本药物的患者历史队列。药品人均支出按随访期进行分层，并根据人口统计学、临床情况和所使用药物类型进行描述。
该项目覆盖的总人口为611,419人，其中女性占63.5%，平均年龄46岁。41.9%的患者居住在巴西东南部，29.7%居住在东北部。24.5%的患者于2000年开始治疗，12.4%于2001年开始治疗，至2004年呈上升趋势。最常见的诊断涉及泌尿生殖系统疾病，最常用的化学药物类别是抗贫血制剂。检测到40,941例死亡（占总数的6.7%）。人均总支出为4,794.34雷亚尔。在巴西东南部居住、47岁、2000年开始治疗、被诊断患有传染病和寄生虫病且使用血液替代品和灌注液的男性中，观察到人均支出较高。
对相关费用的了解有助于为重组行动和药物项目安排提供资金支持，也为作为优先分析对象的治疗组提供信息。
