Institute of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, Belgrade, Serbia.
J Voice. 2012 May;26(3):381-9. doi: 10.1016/j.jvoice.2011.04.004. Epub 2011 Aug 12.
Increasing incidence of laryngeal carcinoma and advancement in diagnostics and therapy methods, have led to constant exploration in that field. Early glottic carcinoma can be treated successfully with several procedures: cordectomy through laryngofissure, laser cordectomy, and radiotherapy. Our objective was to assess the voice quality after these different modalities of treatment.
Prospective controlled study with 69 patients, treated in a 1-year period for glottic Tis and T1a carcinoma at the tertiary medical centre.
Nineteen of our patients were treated endoscopically with CO(2) laser (types III-IV cordectomy according to recommended European Laryngological Society classification of endoscopic cordectomies). Thirty-five patients underwent cordectomy through laryngofissure, 15 patients had radiotherapy. Multidimensional computer analysis of voice and speech was conducted 1, 6, and 12 months after the treatment. Three programs included 14 parameters, which were observed.
While comparing the parameters between the groups, there were significant differences in the values of fundamental frequency (Hz), jitter (%), normalized noise energy (dB), standard deviation of fundamental frequency (Hz), percent silent time (%), and sound-pressure level in the different follow-up periods (P<0.05).
In the long run, patients treated with radiotherapy show better voice quality in comparison with other two groups.
喉癌发病率的增加以及诊断和治疗方法的进步，促使人们不断探索该领域。早期声门型癌可以通过多种方法成功治疗：经喉裂开声带切除术、激光声带切除术和放射治疗。我们的目的是评估这些不同治疗方式后的嗓音质量。
在一家三级医疗中心，对 69 例在 1 年内因声门Tis 和 T1a 癌接受治疗的患者进行前瞻性对照研究。
我们的 19 例患者接受 CO 2 激光内镜治疗（根据欧洲喉科学会内镜声带切除术分类推荐的 III-IV 型声带切除术）。35 例患者接受经喉裂开声带切除术，15 例患者接受放射治疗。治疗后 1、6 和 12 个月，对嗓音和言语进行多维计算机分析。观察了 3 个程序中的 14 个参数。
在比较各组参数时，在不同随访期的基频（Hz）、抖动（%）、归一化噪声能量（dB）、基频标准差（Hz）、无声时间百分比（%）和声压级（dB）值方面存在显著差异（P<0.05）。
从长远来看，与其他两组相比，接受放射治疗的患者的嗓音质量更好。
