Pyruvate dehydrogenase activation by insulin in human circulating lymphocytes and the possible pathway involved.
作者信息
Curto M, Piccinini M, Marino C, Mostert M, Bruno R, Rinaudo M T
机构信息
Dipartimento di Medicina, Università di Torino, Italia.
出版信息
Int J Biochem. 1990;22(1):99-106. doi: 10.1016/0020-711x(90)90084-g.
PMID:2184057
Abstract
- The incubation of human fresh circulating lymphocytes with insulin leads to modifications in the behaviour of the pyruvate dehydrogenase complex (PDH) when the contact medium is supplemented with 50 microM Ca2+ and Mg2+. 2. To investigate the mechanism involved in the PDH responsiveness to insulin in circulating lymphocytes and the role of Ca2+ and Mg2+ in this process, the PDH activity was assayed in lymphocytes combined with insulin and/or a number of substances whose mechanism of action is partially known. 3. Of these some have been seen to mimick insulin effects on PDH, whereas other were tested for the first time in this study.
摘要
相似文献
1
Pyruvate dehydrogenase activation by insulin in human circulating lymphocytes and the possible pathway involved.
Int J Biochem. 1990;22(1):99-106. doi: 10.1016/0020-711x(90)90084-g.
2
Effects of insulin on pyruvate dehydrogenase in circulating lymphocytes from normal and diabetic rats.胰岛素对正常及糖尿病大鼠循环淋巴细胞中丙酮酸脱氢酶的影响。
Int J Biochem. 1988;20(7):667-74. doi: 10.1016/0020-711x(88)90161-9.
3
Insulin modulation of pyruvate dehydrogenase in human circulating lymphocytes.胰岛素对人循环淋巴细胞中丙酮酸脱氢酶的调节作用
Int J Biochem. 1988;20(11):1211-7. doi: 10.1016/0020-711x(88)90221-2.
4
Pyruvate dehydrogenase activity is stimulated by growth hormone (GH) in human mononuclear cells: a new tool to measure GH responsiveness in man.
J Clin Endocrinol Metab. 1992 Jun;74(6):1258-62. doi: 10.1210/jcem.74.6.1592868.
5
Evidence for a role of protein kinase C in the activation of the pyruvate dehydrogenase complex by insulin in Zajdela hepatoma cells.蛋白激酶C在胰岛素激活Zajdela肝癌细胞中丙酮酸脱氢酶复合体过程中的作用证据。
Metabolism. 1994 Aug;43(8):1030-4. doi: 10.1016/0026-0495(94)90185-6.
6
The insulin signal and its effects on the pyruvate dehydrogenase complex in circulating lymphocytes of obese children.肥胖儿童循环淋巴细胞中的胰岛素信号及其对丙酮酸脱氢酶复合物的影响。
Int J Biochem. 1992 May;24(5):831-7. doi: 10.1016/0020-711x(92)90021-r.
7
Partial purification from human mononuclear cells and placental plasma membranes of an insulin mediator which stimulates pyruvate dehydrogenase and suppresses glucose-6-phosphatase.从人单核细胞和胎盘质膜中部分纯化出一种胰岛素介质，该介质可刺激丙酮酸脱氢酶并抑制葡萄糖-6-磷酸酶。
Arch Biochem Biophys. 1984 Dec;235(2):418-26. doi: 10.1016/0003-9861(84)90215-7.
8
Phytohemagglutinin (PHA) activated human T-lymphocytes: concomitant appearance of insulin binding, degradation and insulin-mediated activation of pyruvate dehydrogenase (PDH).植物血凝素（PHA）激活的人T淋巴细胞：胰岛素结合、降解以及胰岛素介导的丙酮酸脱氢酶（PDH）激活的同时出现。
Biochem Biophys Res Commun. 1986 Jan 14;134(1):412-9. doi: 10.1016/0006-291x(86)90579-6.
9
Molecular effects of sulphonylurea agents in circulating lymphocytes of patients with non-insulin-dependent diabetes mellitus.磺酰脲类药物对非胰岛素依赖型糖尿病患者循环淋巴细胞的分子效应。
Br J Clin Pharmacol. 1998 Mar;45(3):291-9. doi: 10.1046/j.1365-2125.1998.00680.x.
10
Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria. Effects of starvation and diabetes.大鼠骨骼肌线粒体中丙酮酸脱氢酶的可逆磷酸化。饥饿和糖尿病的影响。
Biochem J. 1984 Apr 15;219(2):635-46. doi: 10.1042/bj2190635.
引用本文的文献
1
Molecular effects of sulphonylurea agents in circulating lymphocytes of patients with non-insulin-dependent diabetes mellitus.磺酰脲类药物对非胰岛素依赖型糖尿病患者循环淋巴细胞的分子效应。
Br J Clin Pharmacol. 1998 Mar;45(3):291-9. doi: 10.1046/j.1365-2125.1998.00680.x.
Zotero 插件