IVF Unit, Department of Obstetrics and Gynecology, Wolfson Medical Center, Holon, and Sackler Faculty of Medicine, Tel Aviv University, Israel.
Reprod Biomed Online. 2011 Oct;23(4):484-9. doi: 10.1016/j.rbmo.2011.06.004. Epub 2011 Jun 15.
In ovulatory patients, frozen-thawed embryo transfer (FET) is commonly performed during a natural cycle (NC). The objective was to compare serial monitoring until documentation of ovulation with human chorionic gonadotrophin (HCG) triggering, for timing NC-FET. Sixty women with regular menstrual cycles undergoing NC-FET were randomized into two groups: group A (n=30) had FET in a natural cycle after ovulation triggering with HCG; group B (n=30) had FET in a natural cycle after detection of spontaneous ovulation. The main outcome measure was the number of monitoring visits at the clinic per cycle. Secondary outcome measures included implantation rate, clinical pregnancy and live-birth rates. Both groups were similar in terms of demographic characteristics and reproductive history. Clinical and laboratory characteristics of fresh and frozen cycles and pregnancy and delivery rates were comparable for both groups. The number of monitoring visits in group A (3.2 ± 1.4) was significantly lower than in group B (4.7 ± 1.6) (P=0.002). In patients undergoing NC-FET, triggering ovulation by HCG can significantly reduce the number of visits necessary for cycle monitoring without an adverse effect on cycle outcome. Ovulation triggering can increase both patient convenience and cycle cost effectiveness.
在排卵患者中，通常在自然周期（NC）中进行冷冻胚胎移植（FET）。目的是比较直至排卵后 hCG 触发排卵的连续监测与 hCG 触发排卵的时间，以确定 NC-FET 的时间。60 名接受 NC-FET 的月经周期正常的妇女被随机分为两组：A 组（n=30）在 hCG 触发排卵后自然周期中进行 FET；B 组（n=30）在自发排卵后自然周期中进行 FET。主要观察指标为每个周期在诊所的监测就诊次数。次要观察指标包括着床率、临床妊娠率和活产率。两组在人口统计学特征和生殖史方面相似。新鲜和冷冻周期的临床和实验室特征以及妊娠和分娩率在两组之间具有可比性。A 组（3.2±1.4）的监测就诊次数明显少于 B 组（4.7±1.6）（P=0.002）。在接受 NC-FET 的患者中，通过 hCG 触发排卵可以显著减少周期监测所需的就诊次数，而不会对周期结果产生不利影响。排卵触发可以提高患者的便利性和周期的成本效益。
