Laboratory of Integrative and Systems Physiology and Nestle Chair in Energy Metabolism, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Physiology (Bethesda). 2011 Aug;26(4):214-24. doi: 10.1152/physiol.00010.2011.
Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the ability to transcriptionally reprogram the cell and metabolically adapt to external cues. In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span.
饮食限制可以延长迄今为止大多数被测试的生物体的寿命,这表明感知营养和能量可用性的机制可能调节寿命。AMP 激活的蛋白激酶 (AMPK) 已经成为一种关键的能量传感器,能够转录重编程细胞并代谢适应外部信号。在这篇综述中,我们将讨论 AMPK 在热量限制对健康和寿命的有益影响中的可能作用。