Clinique du Landy, Service de Nephrologie et Dialyse, Saint Ouen, France.
Kidney Int. 2011 Sep;80(5):443-5. doi: 10.1038/ki.2011.146.
Parathyroid hormone (PTH) and vitamin D were considered the major factors regulating phosphate homeostasis. Now, with the identification of fibroblast growth factor 23 (FGF23), a phosphaturic molecule inhibiting calcitriol and PTH, they need to be integrated into three feedback loops involving parathyroid, bone, and kidney. PTH and calcitriol are required for the appropriate synthesis of FGF23 by bone cells. PTH also regulates klotho expression in the kidney and thereby the phosphaturic action of FGF23.
甲状旁腺激素 (PTH) 和维生素 D 被认为是调节磷酸盐稳态的主要因素。现在，随着成纤维细胞生长因子 23 (FGF23) 的发现，一种抑制 1,25-二羟维生素 D 和 PTH 的排磷分子，它们需要整合到涉及甲状旁腺、骨骼和肾脏的三个反馈回路中。PTH 和 1,25-二羟维生素 D 是骨细胞适当合成 FGF23 所必需的。PTH 还调节肾脏中 klotho 的表达，从而调节 FGF23 的排磷作用。
