Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de Valencia, Avda. Blasco Ibáñez, 21, 46010 Valencia, Spain.
Neurotoxicol Teratol. 2012 Jan-Feb;34(1):108-15. doi: 10.1016/j.ntt.2011.07.011. Epub 2011 Aug 4.
Many people begin to experiment with alcohol during adolescence, an important developmental period during which sex differences in the effects of ethanol appear. In the present study we evaluated the effect of ethanol (0, 0.625, 1.25 or 2.5 g/kg) on the acquisition of a conditioned place preference (CPP) in early and late adolescent male and female mice. In addition, we assessed the capacity of ethanol to induce reinstatement of the CPP after its extinction. CPP was induced in early and late adolescent females with 2.5 g/kg, and in early adolescent males with 1.25 or 2.5 g/kg of ethanol. No CPP was observed in late adolescent males. Priming with ethanol reinstated the CPP induced by the highest dose in early adolescent male and early and late adolescent female mice. Our data suggest that early adolescents of both sex and late adolescent females are particularly vulnerable to the effects of ethanol.
许多人在青春期开始尝试酒精，这是一个重要的发展阶段，在此期间，乙醇的影响在性别上出现差异。在本研究中，我们评估了乙醇（0、0.625、1.25 或 2.5 g/kg）对早期和晚期青春期雄性和雌性小鼠条件性位置偏好（CPP）获得的影响。此外，我们还评估了乙醇在其消退后诱导 CPP 复燃的能力。用 2.5 g/kg 的乙醇诱导早期和晚期青春期雌性，用 1.25 或 2.5 g/kg 的乙醇诱导早期青春期雄性产生 CPP。晚期青春期雄性没有观察到 CPP。用乙醇引发可使早期青春期雄性和早期及晚期青春期雌性小鼠中最高剂量诱导的 CPP 复燃。我们的数据表明，两性的早期青少年和晚期青春期雌性特别容易受到乙醇的影响。
