Bilgir Oktay, Bilgir Ferda, Calan Mehmet, Kebapcilar Levent, Pamuk Baris, Yuksel Arif
Department of 2nd Internal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
Transfus Apher Sci. 2011 Oct;45(2):149-50. doi: 10.1016/j.transci.2011.07.007. Epub 2011 Aug 16.
Thrombotic thrombocytopenic purpura (TTP) is a syndrome with numerous neurological manifestations including altered mental status and seizures. However, status epilepticus (SE) has rarely been reported in this condition. Signs may be transient or fluctuate; however, permanent deficits do occur. Its prognosis was once considered uniformly poor, with a high mortality rate. Since the introduction of plasma infusions and exchanges, the prognosis of the disease has improved dramatically; remissions now occur in 80-90% of patients. Altered mental status in TTP often resolves with plasmapheresis. Likewise, we successfully treated a patient with thrombotic thrombocytopenic purpura (TTP) with pronounced clinical effects of status epilepticus with plasmapheresis and steroid treatment.
