Palacio Carlos, Alexandraki Irene, Bertholf Roger L, Mooradian Arshag D
Department of Medicine, University of Florida, 653-1 West Eighth Street, Jacksonville, FL 32209, USA.
Ann Clin Lab Sci. 2011 Spring;41(2):150-3.
Tangier disease is a rare genetic disorder of lipid metabolism characterized by low concentrations of plasma high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol with normal or elevated levels of triglycerides. In this case report we describe a patient with diabetes who experienced an episode of urosepsis with a plasma lipid profile resembling Tangier disease. Experimental evidence in the literature suggests that similar lipid changes may occur due to cytokines released during sepsis. Clinicians should be aware of these changes to avoid misdiagnosis of lipid disorders.
丹吉尔病是一种罕见的脂质代谢遗传性疾病，其特征是血浆高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇浓度低，而甘油三酯水平正常或升高。在本病例报告中，我们描述了一名糖尿病患者，其经历了一次尿脓毒症发作，血脂谱类似于丹吉尔病。文献中的实验证据表明，脓毒症期间释放的细胞因子可能导致类似的脂质变化。临床医生应意识到这些变化，以避免脂质紊乱的误诊。
