Department of Physics, London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada.
J Appl Clin Med Phys. 2011 Apr 12;12(3):3505. doi: 10.1120/jacmp.v12i3.3505.
The aims of this study were to investigate the variability between physicians in delineation of head and neck tumors on original tomotherapy megavoltage CT (MVCT) studies and corresponding software enhanced MVCT images, and to establish an optimal approach for evaluation of image improvement. Five physicians contoured the gross tumor volume (GTV) for three head and neck cancer patients on 34 original and enhanced MVCT studies. Variation between original and enhanced MVCT studies was quantified by DICE coefficient and the coefficient of variance. Based on volume of agreement between physicians, higher correlation in terms of average DICE coefficients was observed in GTV delineation for enhanced MVCT for patients 1, 2, and 3 by 15%, 3%, and 7%, respectively, while delineation variance among physicians was reduced using enhanced MVCT for 12 of 17 weekly image studies. Enhanced MVCT provides advantages in reduction of variance among physicians in delineation of the GTV. Agreement on contouring by the same physician on both original and enhanced MVCT was equally high.
本研究的目的是探讨医生在勾画头颈部肿瘤的原始 Tomotherapy 兆伏 CT（MVCT）研究和相应的软件增强 MVCT 图像上的变异性，并建立一种评估图像改善的最佳方法。5 名医生在 34 个头颈部癌症患者的 34 个原始和增强 MVCT 研究中勾画大体肿瘤体积（GTV）。通过 DICE 系数和变异系数量化原始和增强 MVCT 研究之间的差异。基于医生之间的体积一致性，对于患者 1、2 和 3，增强 MVCT 上的 GTV 勾画的平均 DICE 系数的相关性更高，分别为 15%、3%和 7%，而在 17 次每周图像研究中，有 12 次使用增强 MVCT 降低了医生之间的勾画变异性。增强 MVCT 在 GTV 勾画中降低了医生之间的变异性方面具有优势。同一名医生在原始和增强 MVCT 上的勾画具有相同的高一致性。
