Zhang Yibing, Gui Jianfang
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Sheng Wu Gong Cheng Xue Bao. 2011 May;27(5):675-83.
Interferon response is the first line of host defense against virus infection. Recent years have witnessed tremendous progress in understanding of fish innate response to virus infection, especially in fish interferon antiviral response. A line of fish genes involved in interferon antiviral response have been identified and functional studies further reveal that fish possess an IFN antiviral system similar to mammals. However, fish virus-induced interferon genes contain introns similar to mammalian type III interferon genes although they encode proteins similar to type I interferons, which makes it hard to understand the evolution of vertebrate interferon genes directly resulting in a debate on nomenclature of fish interferon genes. Actually, fish display some unique mechanisms underlying interferon antiviral response. This review documents the recent progress on fish interferon response and its molecular mechanism.
干扰素反应是宿主抵御病毒感染的第一道防线。近年来，在了解鱼类对病毒感染的天然免疫反应方面取得了巨大进展，尤其是在鱼类干扰素抗病毒反应方面。一系列参与干扰素抗病毒反应的鱼类基因已被鉴定出来，功能研究进一步表明鱼类拥有类似于哺乳动物的干扰素抗病毒系统。然而，鱼类病毒诱导的干扰素基因含有与哺乳动物III型干扰素基因相似的内含子，尽管它们编码的蛋白质与I型干扰素相似，这使得直接理解脊椎动物干扰素基因的进化变得困难，进而引发了关于鱼类干扰素基因命名的争论。实际上，鱼类在干扰素抗病毒反应中表现出一些独特的机制。本综述记录了鱼类干扰素反应及其分子机制的最新进展。
