Sardyko N V, Golubeva T N, Babenko G A
Zh Mikrobiol Epidemiol Immunobiol. 1990 Jan(1):63-8.
27 patients with chronic candidiasis of the skin and mucous membranes have been examined with a view to study the expression of E-receptors and its changes after the incubation of T-lymphocytes with theophylline, levamisole, thymaline and Candida albicans antigen. This study has revealed that, in comparison with healthy persons, most patients show decreased expression of E-receptors, and the character of their changes after incubation with the above-mentioned preparations is essentially different. The deviations revealed in this study have been regarded as the modification of T-cell membranes, which is seemingly one of the reasons of the weak competence of T-cells. In its turn, the expression of E-receptors may be considered as an indicator of the influence of different factors on T-lymphocytes. Substances altering the level of cyclic nucleotides in the cell, the antigenic fractions of the fungal causative agent, the suppression or blocking the action of thymic hormone-like substances may serve as such factors.
为研究T淋巴细胞与茶碱、左旋咪唑、胸腺素及白色念珠菌抗原孵育后E受体的表达及其变化，对27例皮肤和黏膜慢性念珠菌病患者进行了检查。该研究表明，与健康人相比，大多数患者E受体表达降低，且与上述制剂孵育后其变化特征存在本质差异。本研究中发现的偏差被认为是T细胞膜的改变，这似乎是T细胞功能低下的原因之一。反过来，E受体的表达可被视为不同因素对T淋巴细胞影响的指标。可改变细胞内环核苷酸水平的物质、真菌病原体的抗原成分、抑制或阻断胸腺素样物质的作用等均可作为此类因素。
