State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People's Republic of China.
Biotechnol Adv. 2011 Nov-Dec;29(6):930-9. doi: 10.1016/j.biotechadv.2011.07.022. Epub 2011 Aug 6.
Lactic acid, the most important hydroxycarboxylic acid, is now commercially produced by the fermentation of sugars present in biomass. In addition to its use in the synthesis of biodegradable polymers, lactic acid can be regarded as a feedstock for the green chemistry of the future. Different potentially useful chemicals such as pyruvic acid, acrylic acid, 1,2-propanediol, and lactate ester can be produced from lactic acid via chemical and biotechnological routes. Here, we reviewed the current status of the production of potentially valuable chemicals from lactic acid via biotechnological routes. Although some of the reactions described in this review article are still not applicable at current stage, due to their "greener" properties, biotechnological processes for the production of lactic acid derivatives might replace the chemical routes in the future.
乳酸是最重要的羟基羧酸，目前通过发酵生物质中的糖来商业生产。除了用于合成可生物降解聚合物外，乳酸还可以被视为未来绿色化学的原料。通过化学和生物技术途径，可以从乳酸生产不同的潜在有用化学品，如丙酮酸、丙烯酸、1,2-丙二醇和乳酸酯。在这里，我们综述了通过生物技术途径从乳酸生产潜在有价值化学品的现状。尽管本文中描述的一些反应由于其“更绿色”的特性，在现阶段还不适用，但生物技术生产乳酸衍生物的工艺可能会在未来取代化学路线。
