microRNAs 作为心血管疾病的外周血生物标志物。
microRNAs as peripheral blood biomarkers of cardiovascular disease.
机构信息
Molecular Cardiology Laboratory, IRCCS-Policlinico San Donato, Via Morandi 30, San Donato Milanese, 20097 Milan, Italy.
出版信息
Vascul Pharmacol. 2011 Oct;55(4):111-8. doi: 10.1016/j.vph.2011.08.001. Epub 2011 Aug 6.
PMID:21846509
Abstract
A host of studies have established essential roles for microRNAs in cardiovascular development and disease. Moreover, the discovery of stable microRNAs in bodily fluids indicated their potential as non-invasive biomarkers. In this review, we summarize the current studies describing microRNAs in blood cells or serum/plasma, as potential biomarkers of cardiovascular disease.
摘要
大量研究已经确定了 microRNAs 在心血管发育和疾病中的重要作用。此外，在体液中发现稳定的 microRNAs 表明它们具有作为非侵入性生物标志物的潜力。在这篇综述中，我们总结了目前描述血细胞或血清/血浆中 microRNAs 作为心血管疾病潜在生物标志物的研究。
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