Dimitry Mark O, Soliman Youssef M A, ElKorashy Reem I, Raslan Hala M, Kamel Solaf A, Hassan Eman M, Ahmed Fatma Elzahraa, Yousef Rasha N, Awadallah Eman A
Cardiology Unit, Department of Internal Medicine, National Research Center, Cairo, Egypt.
Pulmonary Vascular Disease Unit, Department of Pulmonology, Cairo University, Cairo, Egypt.
Egypt Heart J. 2023 Aug 30;75(1):76. doi: 10.1186/s43044-023-00395-w.
Pulmonary hypertension "PH" is considered a serious cardiovascular disease. World Health Organization divided PH into groups depending on many factors like pathological, hemodynamic, and clinical pictures. Lately, various micro-RNAs "miRNAs" and other novel biomarkers like endoglin and asymmetric dimethylarginine "ADMA" might have a role in diagnosis of PH and may differentiate between pulmonary arterial hypertension "PAH" and non-PAH. The purpose of the study is to show the role of miR-21, miR-124, endoglin and ADMA in the diagnosis of PH and distinguishing between WHO group 1 PH and WHO group 2 and 3 PH and to identify patients who might benefit from non-invasive and inexpensive tools to diagnose PAH.
miR-21 was upregulated in group 1 PH, and there was significant difference between group 1 PH as compared with group 2 PH, group 3 PH and control; miR-124 was down-regulated in group 1 PH with highly significant difference between group 1 and group 2 PH and control but no significant difference with group 3 PH, endoglin was elevated in group 1 PH with a significant difference as compared to group 2 PH, group 3 PH and control. ADMA was elevated in group 1 PH as compared to control; however, there was no significant difference between it and group 2, 3 PH.
miR-21, miR-124, endoglin and ADMA are good biomarkers to diagnose PH; however, only miR-21 and endoglin could distinguish group 1 PH from group 2 and 3 PH.
肺动脉高压（PH）被认为是一种严重的心血管疾病。世界卫生组织根据病理、血流动力学和临床表现等多种因素将PH分为不同类型。最近，各种微小RNA（miRNA）以及其他新型生物标志物如内皮糖蛋白和不对称二甲基精氨酸（ADMA）可能在PH的诊断中发挥作用，并且可能有助于区分肺动脉高压（PAH）和非PAH。本研究的目的是展示miR-21、miR-124、内皮糖蛋白和ADMA在PH诊断中的作用，以及区分世界卫生组织第1组PH与第2组和第3组PH，并识别可能从无创且廉价的工具诊断PAH中受益的患者。
miR-21在第1组PH中上调，第1组PH与第组2 PH、第3组PH和对照组相比存在显著差异；miR-124在第1组PH中下调，第1组与第2组PH和对照组之间存在高度显著差异，但与第3组PH无显著差异，内皮糖蛋白在第1组PH中升高，与第2组PH、第3组PH和对照组相比有显著差异。与对照组相比，第1组PH中ADMA升高；然而，它与第2组、第3组PH之间无显著差异。
miR-21、miR-124、内皮糖蛋白和ADMA是诊断PH的良好生物标志物；然而，只有miR-21和内皮糖蛋白能够区分第1组PH与第2组和第3组PH。
