Atherosclerosis and PTPN22: a study in coronary artery disease.

作者信息

Saccucci P, Banci M, Cozzoli E, Neri A, Magrini A, Bottini E, Gloria-Bottini F

机构信息

Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy.

出版信息

Cardiology. 2011;119(1):54-6. doi: 10.1159/000329919. Epub 2011 Aug 12.

OBJECTIVES

Recently, it has been shown that PTPN22 genetic polymorphism is associated with phenotypes related to the risk of atherosclerosis. In the present note, we have searched for a possible association of PTPN22 polymorphism with coronary artery disease (CAD).

METHODS

One hundred and thirty-four non-diabetic subjects admitted to hospital for CAD and 174 healthy subjects (blood donors) were studied. PTPN22 genotypes were determined by DNA analysis. Statistical analyses were performed by SPSS programs.

RESULTS

In CAD patients, the proportion of carriers of the *T allele of PTPN22 is significantly higher compared to healthy controls (OR 2.66; 95% CI 1.07-6.72).

CONCLUSIONS

The present observation confirms the association of PTPN22 phenotype with atherosclerosis and suggests a role of immune mechanism in the pathogenesis of CAD.