Opie L H, Clusin W T
Medical Research Council/University of Cape Town Ischemic Heart Disease Research Unit, University of Cape Town Medical School, South Africa.
Annu Rev Med. 1990;41:231-8. doi: 10.1146/annurev.me.41.020190.001311.
Two of the major ionic abnormalities found early in ischemia are (a) loss of potassium with an increase in the extracellular potassium ion concentration and (b) an increase in free cytosolic calcium. Both of these ionic abnormalities can powerfully predispose to the development of arrhythmias.
(a) 钾离子丢失，细胞外钾离子浓度升高；(b) 游离胞质钙增加。这两种离子异常都极易引发心律失常。
