锂盐长期治疗对精神科患者甲状腺功能的影响。
Effects of long-term lithium carbonate treatment on thyroid function in psychiatric patients.
机构信息
Professor of Psychiatry, Christian Medical College & Hospital, Vellore.
出版信息
Indian J Psychiatry. 1983 Apr;25(2):98-101.
The effect of long-term lithium carbonate treatment on thyroid function was investigated in 40 clinically euthyroid patients with Manic Depressive Psychosis. Before lithium treatment, all patients showed normal levels (T(4)) of serum total thyroxine, free thyroxine index and thyrotropin (TSH). After lithium carbonate treatment for a mean period of 24 months, these patients did not show any significant change in the mean values of serum total T(4), free thyroxine index and TSH. None showed clinical symptoms of goitre and hypothyroidism after long-term lithium treatment. It is concluded that lithium therapy in euthyroid psychiatric patients has no adverse effect on thyroid function and en the pituitary secretion of TSH.
我们研究了 40 例临床甲状腺功能正常的躁狂抑郁症患者长期碳酸锂治疗对甲状腺功能的影响。锂治疗前，所有患者的血清总甲状腺素（T4）、游离甲状腺素指数和促甲状腺素（TSH）水平均正常。碳酸锂治疗平均 24 个月后，患者血清总 T4、游离甲状腺素指数和 TSH 的均值均无显著变化。长期锂治疗后，无患者出现甲状腺肿和甲状腺功能减退的临床症状。结论：锂治疗对甲状腺功能正常的精神科患者无不良影响，对垂体 TSH 的分泌也无影响。
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