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αB-晶状体蛋白是一种与乳腺癌预后不良相关的新型癌蛋白。

αB-Crystallin is a Novel Oncoprotein Associated with Poor Prognosis in Breast Cancer.

机构信息

Division of Breast and Endocrine Surgery, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

出版信息

J Breast Cancer. 2011 Mar;14(1):14-9. doi: 10.4048/jbc.2011.14.1.14. Epub 2011 Mar 31.

DOI:10.4048/jbc.2011.14.1.14
PMID:21847389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3148513/
Abstract

PURPOSE

αB-crystallin, a small heat shock protein, is an anti-apoptotic protein associated with aggressive tumor behavior. A recent study revealed that αB-crystallin is overexpressed in a metastatic variant of the GI101A human breast carcinoma cell line. The purpose of this study was to investigate whether αB-crystallin is related to other breast tumor markers and can predict a breast cancer prognosis.

METHODS

Eighty-two patients who underwent breast cancer surgery at Hallym Sacred Heart Hospital were enrolled. αB-crystallin expression was determined by immunohistochemical staining. Estrogen receptor, progesterone receptor (PR), human epidermal growth factor receptor, lymphovascular invasion, histological grade, other tumor markers and time to recurrence were compared with αB-crystallin expression.

RESULTS

αB-crystallin expression in breast cancer tissues was associated with PR (p=0.030), the number of metastatic lymph nodes (pN) (p=0.020), lymphovascular invasion (p=0.022), histological grade (p=0.004) and triple negative breast cancer (TNBC) (p=0.004). αB-crystallin expression significantly decreased time to recurrence (p=0.039).

CONCLUSION

The results revealed a strong relationship between αB-crystallin and poor prognostic factors such as the number of metastatic lymph nodes (especially pN2), TNBC, and rapid time to recurrence. We believe that αB-crystallin could be a novel oncoprotein biomarker of a poor prognosis in breast cancer.

摘要

目的

αB-晶状体蛋白是一种小热休克蛋白，是一种与侵袭性肿瘤行为相关的抗凋亡蛋白。最近的一项研究表明，αB-晶状体蛋白在 GI101A 人乳腺癌细胞系的转移变体中过表达。本研究旨在探讨αB-晶状体蛋白是否与其他乳腺癌标志物相关，并能预测乳腺癌的预后。

方法

在翰林圣心医院接受乳腺癌手术的 82 名患者被纳入本研究。通过免疫组织化学染色检测αB-晶状体蛋白的表达。比较雌激素受体、孕激素受体（PR）、人表皮生长因子受体、脉管侵犯、组织学分级、其他肿瘤标志物与αB-晶状体蛋白表达的关系。

结果

αB-晶状体蛋白在乳腺癌组织中的表达与 PR（p=0.030）、转移性淋巴结数（pN）（p=0.020）、脉管侵犯（p=0.022）、组织学分级（p=0.004）和三阴性乳腺癌（TNBC）（p=0.004）有关。αB-晶状体蛋白的表达与复发时间显著相关（p=0.039）。

结论

结果表明，αB-晶状体蛋白与不良预后因素（尤其是 pN2 转移性淋巴结数、TNBC 和快速复发时间）之间存在强烈关系。我们认为，αB-晶状体蛋白可能是乳腺癌预后不良的一种新的癌蛋白生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/d805ab472b4a/jbc-14-14-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/b98ffb0b0f4f/jbc-14-14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/c437d5bcb88d/jbc-14-14-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/3e8850fa9d83/jbc-14-14-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/d805ab472b4a/jbc-14-14-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/b98ffb0b0f4f/jbc-14-14-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/c437d5bcb88d/jbc-14-14-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/3e8850fa9d83/jbc-14-14-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4044/3148513/d805ab472b4a/jbc-14-14-g004.jpg

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