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[具体内容]在肿瘤预后和免疫浸润中的作用：一项泛癌分析。 （你提供的原文中“of”后面缺少具体内容）

The role of in tumor prognosis and immune infiltration: A Pan-cancer analysis.

作者信息

Cheng Lang, Zou Xiong, Wang Jiawei, Zhang Jiange, Mo Zengnan, Huang Houbao

机构信息

Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.

Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

出版信息

Front Surg. 2023 Jan 13;9:1117307. doi: 10.3389/fsurg.2022.1117307. eCollection 2022.

DOI:10.3389/fsurg.2022.1117307
PMID:36713654
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9880180/
Abstract

PURPOSE

There is evidence that the Crystallin Alpha B gene is involved in the regulation of the tumor microenvironment and influences tumor prognosis in some cancers. However, the role of gene in prognosis and immunology in pan-cancer is still unclear.

METHODS

In this study, we analyzed the transcriptional profiles and survival data of cancer patients from The Cancer Genome Atlas (TCGA) database. gene and its relationships with pan-cancer were analyzed using R packages, TIMER2.0, GEPIA2, Sangerbox, UALCAN, cBioPortal, ESTIMATE algorithm, and STRING. Besides, real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) was utilized to detect expression in KIRC and a human KIRC cell line (Caki-1).

RESULTS

We found that expression was different in tumors and adjacent tumors in human cancers, affecting patients' prognosis in 15 cancer types. Additionally, expression significantly correlated with tumor microenvironment (TME), immune checkpoints (ICP), tumor mutational burden (TMB), and microsatellite instability (MSI) in human cancers. Besides, expression was positively associated with the immune infiltration of cancer-associated fibroblasts (CAFs) and endothelial cells in most human cancers. Based on enrichment analysis, the most prevalent gene mechanism in malignant tumors may be through anti-apoptotic activity. Moreover, some FDA-approved drugs were found to be associated with and might be potential cancer therapeutic candidates.

CONCLUSIONS

is a crucial component of the TME and influences immune cell infiltration, making it a promising biomarker to assess immune infiltration and prognosis in many malignancies.

摘要

目的

有证据表明，αB晶状体蛋白基因参与肿瘤微环境的调节，并影响某些癌症的肿瘤预后。然而，该基因在泛癌中的预后和免疫学作用仍不清楚。

方法

在本研究中，我们分析了来自癌症基因组图谱（TCGA）数据库的癌症患者的转录谱和生存数据。使用R包、TIMER2.0、GEPIA2、Sangerbox、UALCAN、cBioPortal、ESTIMATE算法和STRING分析该基因及其与泛癌的关系。此外，利用实时荧光定量聚合酶链反应（RT-qPCR）检测肾透明细胞癌（KIRC）和人KIRC细胞系（Caki-1）中的该基因表达。

结果

我们发现该基因在人类癌症的肿瘤和邻近肿瘤中的表达不同，影响15种癌症类型患者的预后。此外，该基因表达与人类癌症中的肿瘤微环境（TME）、免疫检查点（ICP）、肿瘤突变负担（TMB）和微卫星不稳定性（MSI）显著相关。此外，在大多数人类癌症中，该基因表达与癌症相关成纤维细胞（CAF）和内皮细胞的免疫浸润呈正相关。基于富集分析，恶性肿瘤中最普遍的该基因机制可能是通过抗凋亡活性。此外，发现一些美国食品药品监督管理局（FDA）批准的药物与该基因相关，可能是潜在的癌症治疗候选药物。

结论

该基因是肿瘤微环境的关键组成部分，影响免疫细胞浸润，使其成为评估许多恶性肿瘤免疫浸润和预后的有前景的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/4f08df103bfb/fsurg-09-1117307-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/0b7654d14675/fsurg-09-1117307-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/20c86614dbdb/fsurg-09-1117307-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/52398b8c80fc/fsurg-09-1117307-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/ca87b91946c1/fsurg-09-1117307-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/03ae44a19636/fsurg-09-1117307-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/2f526e04e73f/fsurg-09-1117307-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/dafc684b68c0/fsurg-09-1117307-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/76483a2826b2/fsurg-09-1117307-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/4e521d042769/fsurg-09-1117307-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/4f08df103bfb/fsurg-09-1117307-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/0b7654d14675/fsurg-09-1117307-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/20c86614dbdb/fsurg-09-1117307-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/52398b8c80fc/fsurg-09-1117307-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/ca87b91946c1/fsurg-09-1117307-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/03ae44a19636/fsurg-09-1117307-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/2f526e04e73f/fsurg-09-1117307-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/dafc684b68c0/fsurg-09-1117307-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/76483a2826b2/fsurg-09-1117307-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/4e521d042769/fsurg-09-1117307-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/310a/9880180/4f08df103bfb/fsurg-09-1117307-g010.jpg

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本文引用的文献

1
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Int J Pharm. 2022 Aug 25;624:122049. doi: 10.1016/j.ijpharm.2022.122049. Epub 2022 Jul 22.
2
Construction of an immune-related lncRNA signature pair for predicting oncologic outcomes and the sensitivity of immunosuppressor in treatment of lung adenocarcinoma.构建免疫相关 lncRNA 特征对预测肺腺癌的肿瘤学结局和免疫抑制剂治疗的敏感性。
Respir Res. 2022 May 13;23(1):123. doi: 10.1186/s12931-022-02043-4.
3
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Int J Mol Sci. 2024 Dec 3;25(23):12984. doi: 10.3390/ijms252312984.
4
LncRNA is correlated with prognosis and immune infiltration and facilitates tumor progression by targeting in colorectal cancer.长链非编码RNA（LncRNA）与结直肠癌的预后和免疫浸润相关，并通过靶向作用促进肿瘤进展。
Transl Cancer Res. 2024 Oct 31;13(10):5347-5364. doi: 10.21037/tcr-24-378. Epub 2024 Oct 18.
5
Plasma alpha B crystallin as potential biomarker for predicting pre-operative seizures in glioma.血浆 αB 晶体蛋白作为预测脑胶质瘤术前癫痫的潜在生物标志物。
BMC Neurol. 2024 Jul 6;24(1):237. doi: 10.1186/s12883-024-03740-x.
Hallmarks of Cancer: New Dimensions.
癌症的特征：新视角。
Cancer Discov. 2022 Jan;12(1):31-46. doi: 10.1158/2159-8290.CD-21-1059.
4
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PeerJ. 2021 Dec 10;9:e12578. doi: 10.7717/peerj.12578. eCollection 2021.
5
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Mol Cancer. 2021 Oct 11;20(1):131. doi: 10.1186/s12943-021-01428-1.
6
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7
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8
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9
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10
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Cell Mol Life Sci. 2021 Jan;78(2):661-673. doi: 10.1007/s00018-020-03517-8. Epub 2020 Apr 23.