Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.
J Breast Cancer. 2011 Jun;14(2):160-4. doi: 10.4048/jbc.2011.14.2.160. Epub 2011 Jun 18.
Acinic cell carcinoma (ACC) of the breast is extremely rare and is characterized by widespread acinar cell-like differentiation. We report of a 39-year-old woman presented with a palpable breast mass with significant morphological, immunohistochemical and ultrastructural findings. Histologically, ACC showed a diffuse glandular infiltrative pattern, with small acinar or glandular structures mixed with solid nests. Neoplastic cells were monotonous proliferation of cells with a granular or clear cytoplasm, resembling acinar cells of the salivary glands or Paneth cells. Both glandular and solid tumor cell populations were strongly positive for lysozyme and α-1-antitrypsin.
乳腺的腺样囊性癌（ACC）极其罕见，其特征是广泛的腺泡细胞样分化。我们报告了一位 39 岁女性，她因可触及的乳腺肿块就诊，具有显著的形态学、免疫组织化学和超微结构表现。组织学上，ACC 表现为弥漫性腺体浸润模式，伴有小的腺泡或腺体结构与实性巢混合。肿瘤细胞呈均匀一致的细胞增生，具有颗粒状或透明细胞质，类似于唾液腺的腺泡细胞或 Paneth 细胞。腺体和实性肿瘤细胞群体均强烈表达溶菌酶和α-1-抗胰蛋白酶。
