Leighton R F, Repka F J, Birk T J, Lynch D J, Bingle J F, Gohara A F, Saffran J, Weaver M T, Brewster P M, Walsh M E
Department of Medicine, School of Medicine, Medical College of Ohio, Toledo 43699.
Arch Intern Med. 1990 May;150(5):1016-20.
This study was designed to test whether an exercise program is additive to diet counseling in lowering elevated blood cholesterol levels. From a screened population of 1024 subjects, we randomized 66 predominantly female subjects to two intervention groups: diet counseling and diet counseling with exercise. Subjects were selected who had elevated levels of serum low-density lipoprotein cholesterol, an average or low fitness level, and a diet high in saturated fat and cholesterol. After 26 weeks of intervention, 51 subjects exhibited significant decreases in serum levels of cholesterol, high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein cholesterol. The addition of exercise to diet counseling resulted in improved aerobic capacity, losses of body fat and weight, and further nonsignificant decreases in serum cholesterol and low-density lipoprotein cholesterol levels. Since these results differ from data acquired in individuals with normal to borderline serum cholesterol levels, further studies appear indicated in hypercholesterolemic subjects, especially in women.
本研究旨在测试运动计划在降低升高的血液胆固醇水平方面是否能辅助饮食咨询。从1024名经过筛选的受试者群体中，我们将66名以女性为主的受试者随机分为两个干预组：饮食咨询组和饮食咨询加运动组。入选的受试者血清低密度脂蛋白胆固醇水平升高、身体适应能力平均或较低，且饮食中饱和脂肪和胆固醇含量高。经过26周的干预后，51名受试者的血清胆固醇、高密度脂蛋白胆固醇、甘油三酯和低密度脂蛋白胆固醇水平显著下降。在饮食咨询基础上增加运动可提高有氧能力、减少体脂和体重，并使血清胆固醇和低密度脂蛋白胆固醇水平进一步出现不显著下降。由于这些结果与血清胆固醇水平正常至临界的个体所获得的数据不同，因此似乎有必要对高胆固醇血症患者，尤其是女性进行进一步研究。
