Nosal A, Schleissner L A, Mishkin F S, Lieberman J
Ann Intern Med. 1979 Mar;90(3):328-31. doi: 10.7326/0003-4819-90-3-328.
Angiotensin-converting enzyme assays and gallium-scan results were obtained from 27 patients with biopsy-proven, clinically active sarcoidosis. Twenty-three of these patients had elevated converting enzyme levels, and 22 had positive gallium-scan results. Three of four patients with normal or borderline-elevated levels of angiotensin-converting enzyme also had positive gallium-scan results. Of 156 nonsarcoid patients (pulmonary and other diseases), 27 were found to have elevated serum converting enzyme levels, and 25 of these had negative gallium-scan results. These results indicate that the combination of an assay of angiotensin-converting enzyme and gallium scan increases diagnostic specificity from 83% to 99% without sacrificing sensitivity. We conclude that the concurrent use of angiotensin-converting enzyme assay and gallium scan is of value in the diagnosis of sarcoidosis.
对27例经活检证实为临床活动期结节病的患者进行了血管紧张素转换酶检测和镓扫描。其中23例患者的转换酶水平升高，22例镓扫描结果呈阳性。血管紧张素转换酶水平正常或临界升高的4例患者中有3例镓扫描结果也呈阳性。在156例非结节病患者（肺部疾病和其他疾病）中，发现27例血清转换酶水平升高，其中25例镓扫描结果为阴性。这些结果表明，血管紧张素转换酶检测和镓扫描相结合可将诊断特异性从83%提高到99%，且不牺牲敏感性。我们得出结论，同时使用血管紧张素转换酶检测和镓扫描对结节病的诊断具有价值。
