Institut für Pathologie, Technische Universität Dresden, D-01307 Dresden, Germany.
Biol Chem. 2011 Nov;392(11):1047-51. doi: 10.1515/BC.2011.166.
High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.
高肿瘤组织中肿瘤生物学因子 uPAR、uPAR-del4/5 或 rab31 的 mRNA 表达与乳腺癌患者的无远处转移生存期和总生存期较短相关。为了评估这些因素在卵巢癌中是否也具有临床相关性，我们在晚期卵巢癌患者（n=103）的原发肿瘤组织中定量了各自的 mRNA 水平，并评估了它们与临床病理参数和患者预后的关系。这三个标志物的 mRNA 表达水平与总生存期或无进展生存期均无显著相关性，表明这些因素在晚期卵巢癌中没有预后价值。
