Whiting P H, Thomson K J, Saunders N J, Simpson J G
Department of Clinical Biochemistry and Pathology, University of Aberdeen, UK.
J Exp Pathol (Oxford). 1990 Apr;71(2):245-55.
The effects of administering cyclosporin A (CsA), for periods of up to 84 days, on glucose homeostasis and renal function were studied in adult male Sprague-Dawley rats. Marked glucose intolerance was demonstrated at a variety of drug doses, accompanied in the longer term by hyperglycaemia. Early on and at high CsA dose, the abnormal islet cell function was accompanied by islet cell vacuolation; in the long-term dose groups, more chronic structural islet changes were present. Although abnormalities in renal function and structure were noted during this study, they were not directly related to the pancreatic changes observed.
在成年雄性斯普拉格-道利大鼠中研究了长达84天给予环孢素A（CsA）对葡萄糖稳态和肾功能的影响。在各种药物剂量下均表现出明显的葡萄糖不耐受，长期伴有高血糖症。在早期和高CsA剂量下，胰岛细胞功能异常伴有胰岛细胞空泡化；在长期给药组中，存在更慢性的胰岛结构变化。尽管在本研究中注意到肾功能和结构异常，但它们与观察到的胰腺变化没有直接关系。
