Lucke S, Radloff E, Laube R, Hahn H J
Central Institute of Diabetes Gerhardt Katsch, Karlsburg, FRG.
Anat Anz. 1991;172(5):351-8.
The toxic effect of Cyclosporin A (CS-A) (1.25-50.0 mg/kg body weight) on the endocrine pancreas of Wistar rats was morphologically investigated. The treatment of animals with CS-A doses above 5 mg/kg for 2 weeks resulted in a disturbed glucose tolerance, a reduced B-cell volume density and degranulation, vacuolization and decreased mitotic activity of the B-cells. After withdrawal of the drug the impaired parameters were stepwise normalized, starting with regranulation of pancreatic B-cells, followed by a stimulation of mitotic activity, and increase of B-cell volume density. When continuing the CS-A treatment with doses lower than 5.0 mg/kg for longer periods we observed a decreased body weight gain and reduced pancreatic insulin content.
对环孢素A（CS - A）（1.25 - 50.0毫克/千克体重）对Wistar大鼠内分泌胰腺的毒性作用进行了形态学研究。用高于5毫克/千克的CS - A剂量处理动物2周导致葡萄糖耐量紊乱、B细胞体积密度降低、脱颗粒、空泡化以及B细胞有丝分裂活性降低。停药后，受损参数逐步恢复正常，首先是胰腺B细胞重新形成颗粒，随后是有丝分裂活性增强，B细胞体积密度增加。当用低于5.0毫克/千克的剂量持续进行CS - A处理更长时间时，我们观察到体重增加减少和胰腺胰岛素含量降低。
