Maes M, Jacobs M P, Suy E, Vandewoude M, Minner B, Raus J
Psychiatric Center, St-Jozef, Belgium.
Biol Psychiatry. 1990 Apr 15;27(8):854-62. doi: 10.1016/0006-3223(90)90466-f.
Several authors have shown that the availability of L-tryptophan (L-TRP) in the serum is lower in patients with major depression than in controls. It has recently been reported that the administration of a dose of dexamethasone sufficient to cause cortisol suppression also caused significant decrements in the availability of L-TRP. In order to elucidate the putative pathophysiological mechanisms underlying this decreased L-TRP disposition, the authors examined 37 depressed women categorized according to the DSM-III. L-TRP, the sum of five competing amino acids (CAA), the L-TRP/CAA ratio, and insulin and free fatty acid (FFA) levels were determined both before and after oral administration of 1 mg dexamethasone. The availability of L-TRP was significantly lower in depressed women with melancholia compared with simple major and minor depressives. The baseline disposal of L-TRP was related neither to insulin nor to FFA concentrations Dexamethasone administration significantly reduced the L-TRP and L-TRP/CAA values and increased FFA and insulin levels. Postdexamethasone L-TRP and FFA levels were significantly and positively correlated.
几位作者已表明，重度抑郁症患者血清中L-色氨酸（L-TRP）的可利用性低于对照组。最近有报道称，给予足以导致皮质醇抑制的地塞米松剂量也会使L-TRP的可利用性显著降低。为了阐明这种L-TRP处置减少背后的假定病理生理机制，作者对37名根据《精神疾病诊断与统计手册第三版》（DSM-III）分类的抑郁症女性进行了检查。在口服1毫克地塞米松之前和之后，分别测定L-TRP、五种竞争性氨基酸（CAA）的总和、L-TRP/CAA比值以及胰岛素和游离脂肪酸（FFA）水平。与单纯的重度和轻度抑郁症患者相比，伴有忧郁症的抑郁症女性中L-TRP的可利用性显著更低。L-TRP的基线处置与胰岛素浓度和FFA浓度均无关。给予地塞米松显著降低了L-TRP和L-TRP/CAA值，并提高了FFA和胰岛素水平。地塞米松给药后的L-TRP和FFA水平显著正相关。
