Maes M, De Ruyter M, Hobin P, Suy E
Psychiatry Res. 1987 Aug;21(4):323-35. doi: 10.1016/0165-1781(87)90016-3.
Levels of L-tryptophan (L-TRP), of the competing amino acids (CAA) valine and leucine, and of postdexamethasone cortisol taken at 8 a.m., 4 p.m., and 11 p.m. were determined in serum samples from 140 depressive patients. The relationships between postdexamethasone cortisol values, the CAA, and the L-TRP/CAA ratio were assessed using Pearson and Spearman correlation coefficients and multiple regression. There was a significant correlation between postdexamethasone cortisol and both L-TRP and the L-TRP/CAA ratio. The highest correlation coefficients were obtained for the 8 a.m. cortisol values. Nonsuppressors, in comparison with suppressors, showed a significantly lower L-TRP value and L-TRP/CAA ratio.
测定了140例抑郁症患者血清样本中L-色氨酸（L-TRP）、竞争性氨基酸（CAA）缬氨酸和亮氨酸以及上午8点、下午4点和晚上11点采集的地塞米松后皮质醇水平。使用Pearson和Spearman相关系数以及多元回归评估地塞米松后皮质醇值、CAA和L-TRP/CAA比值之间的关系。地塞米松后皮质醇与L-TRP和L-TRP/CAA比值均存在显著相关性。上午8点的皮质醇值相关性系数最高。与抑制者相比，非抑制者的L-TRP值和L-TRP/CAA比值显著更低。
