Joseph M S, Brewerton T D, Reus V I, Stebbins G T
Psychiatry Res. 1984 Mar;11(3):185-92. doi: 10.1016/0165-1781(84)90067-2.
We examined the ratio of plasma L-tryptophan (L-TRP) to other neutral amino acids (NAA) in normal controls and depressed patients undergoing a dexamethsone suppression test (DST). The L-TRP/NAA ratio discriminated controls from patients; however, there was no difference in the mean L-TRP/NAA ratio between DST suppressors and nonsuppressors. The cortisol level measured at 1600h postdexamethasone and the L-TRP/NAA ratio were positively correlated. The 1600h postdexamethasone cortisol levels accounted for 24% of the variance of Hamilton Depression Rating Scale ( HDRS ) scores. The inclusion of L-TRP/NAA ratios with 1600h postdexamethasone cortisol levels in a multiple regression equation resulted in an increase in this value and accounted for 65% of the variance in HDRS scores. The finding supports the use of multivariate biological models in depression.
我们检测了正常对照组以及接受地塞米松抑制试验（DST）的抑郁症患者血浆中L-色氨酸（L-TRP）与其他中性氨基酸（NAA）的比例。L-TRP/NAA比例可区分对照组和患者；然而，DST抑制者与非抑制者之间的平均L-TRP/NAA比例并无差异。地塞米松给药后16:00测得的皮质醇水平与L-TRP/NAA比例呈正相关。地塞米松给药后16:00的皮质醇水平占汉密尔顿抑郁量表（HDRS）评分方差的24%。将L-TRP/NAA比例与地塞米松给药后16:00的皮质醇水平纳入多元回归方程，使得该值增加，并占HDRS评分方差的65%。这一发现支持在抑郁症研究中使用多变量生物学模型。
