Department for Plastic-, Reconstructive and Handsurgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str,13, 67071 Ludwigshafen, Germany.
BMC Musculoskelet Disord. 2011 Aug 17;12:187. doi: 10.1186/1471-2474-12-187.
Osteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive family anamnesis or early menopause are assumed to correlate with reduced BMD.
In our study of 78 patients with metaphyseal long bone fractures, we searched for a correlation between anamnestic risk factors, bone specific laboratory values, and the bone morphogenic density (BMD). Each indicator was examined as a possible diagnostic instrument for osteoporosis. The secondary aim of this study was to demonstrate the high prevalence of osteoporosis in patients with metaphyseal fractures.
76.9% of our fracture patients had decreased bone density and 43.6% showed manifest osteoporosis in DXA (densitometry) measurements. Our questionnaire, identifying anamnestic risk factors, correlated highly significantly (p = 0.01) with reduced BMD, whereas seven bone-specific laboratory values (p = 0.046) correlated significantly.
Anamnestic risk factors correlate with pathological BMD. The medical questionnaire used in this study would therefore function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients.
骨质疏松症是全球范围内的一个主要健康问题，被列入世界卫生组织的十大主要疾病之列。然而，由于患者教育不足和缺乏筛查测试的保险覆盖，直到第一次骨折发生时，这种疾病往往才被诊断出来。阳性家族史或早绝经等既往危险因素被认为与 BMD 降低有关。
在我们对 78 例干骺端长骨骨折患者的研究中，我们探讨了既往危险因素、骨特异性实验室值与骨形态发生密度（BMD）之间的相关性。每个指标都被作为骨质疏松症的可能诊断工具进行了检查。本研究的次要目的是证明干骺端骨折患者中骨质疏松症的高发率。
我们骨折患者中有 76.9%的人骨密度降低，43.6%的人在 DXA（骨密度仪）测量中表现出明显的骨质疏松症。我们的问卷确定了既往危险因素，与 BMD 降低高度相关（p = 0.01），而 7 项骨特异性实验室值（p = 0.046）也显著相关。
既往危险因素与病理性 BMD 相关。因此，本研究中使用的医疗问卷可作为一种经济有效的初步诊断工具，用于识别骨质疏松症患者。
